肠道菌群对中药糖苷类成分脱糖基代谢的研究进展

Advance in studies on gut microbiota in de-glycosylation of traditional Chinese medicine glycosides

中药糖苷类成分是中药中一类重要的活性物质,其药理活性、药代动力学特征及体内存在是目前研究的热点。糖苷类成分在生物体内代谢转化途径主要是由肠道菌群介导的脱糖基代谢,生成苷元后更易吸收入血并发挥药效。该文基于肠道菌群在中药糖苷类成分体内代谢及药效发挥中的重要作用,综述了肠道菌群中代谢中药糖苷类成分的主要糖苷酶,产生糖苷酶的主要菌属,以及代表性糖苷类成分的脱糖基代谢途径。并针对肠道菌群对中药糖苷类成分代谢研究过程中存在的问题进行了初步探讨。

Glycosides are important active components in traditional Chinese medicine （TCM）. Their pharmacological activity, pharmacokinetic characteristics and in vivo existence become hotspots of current studies. The metabolic pathways of these glycosides are de-glycosylation mainly mediated by gut microbiota. After glycosides were metabolized into aglycones, they could be absorbed more easily and show better pharmacological effects. In this article, we reviewed the main glycosidase in gut microbiota which helps metabo- lize TCM glycosides, relevant bacterial strains which generate glycosidase, as well as the de-glycosylated metabolic pathways of the rep- resentative glycosides, on the basis of gut microbiota＇s important roles in in vivo metabolism and efficacy of TCM glycosides. We also preliminarily solved problems in studies on de-glycosylation of TCM glycosides.