中药对铂类抗肿瘤药物的减毒增效作用研究进展

Advances in Research on the Effects of Traditional Chinese Medicines on Platinum Antitumor Drugs

铂配合物具有广谱抗肿瘤活性,在恶性肿瘤化疗中占有举足轻重的地位。但该类药物也存在肾毒性、胃肠道毒性、耳毒性、造血系统毒性和神经系统毒性等严重毒副作用,使其临床应用大大受限。近来研究表明,中药在防治化疗毒副作用和提高肿瘤细胞化疗敏感性等方面表现出明显优势。综述了中药对铂类抗肿瘤药物的减毒增效作用研究进展。

Platinum complexes have a broad spectrum of antitumor activity and play an important role in the chemotherapy of malignant tumors. However, their clinical applications are limited due to the serious toxic and side effects such as nephrotoxicity, gastrointestinal toxicity, ototoxicity, hematopoietic system toxicity, nervous system toxicity, etc.. Recently, some Traditional Chinese Medicines show great potentials to enhance the efficacy and diminish the side effects when used in combination with platinum antitumor drugs. The advances in research on the effects of Traditional Chinese Medicines on platinum antitumor drugs were reviewed in this paper.