急性冠状动脉综合征患者血清hs-CRP水平与冠状动脉病变的相关性

Correlation of high sensitive C-reactive protein with Gensini score in patients with acute coronary syndrome

目的探讨急性冠脉综合征(ACS)患者血清超敏C-反应蛋白(hs-CRP)水平与冠状动脉病变程度的关系及临床意义。方法 60例急性冠脉综合征患者(30例AMI患者和30例UAP患者)作为研究组,30例健康体检者作为对照组;所有人均取外周静脉血检测血清超敏C-反应蛋白(hs-CRP)。冠状动脉病变按Gensini评分,分析血清超敏C-反应蛋白(hs-CRP)水平与Gensini评分的关系。结果与对照组比较,研究组hs-CRP明显增高,差异有统计学意义(P<0.01);AMI组和UAP组Gensini评分的差异具有统计学意义(P<0.01);相关性检验显示ACS患者血清hs-CRP水平与Gensini评分成正相关(r=0.722,P<0.01)。结论急性冠脉综合征患者血清超敏C-反应蛋白(hs-CRP)水平与冠状动脉病变程度密切相关,提示hs-CRP可作为评估ACS病情严重程度的一个指标。

Objective To investigate the correlation between high sensitive C-reactive protein（hs-CRP）in serum and Gensini score in patients with acute coronary syndrome （ACS）. Methods Sixty patients with ACS were enrolled in this study, including 30 patients with acute myocardial infarction（AMI） and 30 patients with unstable angina pectoris（UAP）. Thirty healthy subjects were chosen as controls. The lesions of coronary arteries were assessed. The relation of the serum level of hs-CRP with Gensini score was analyzed. Results The level of hs-CRP in serum was significantly higher in ACS group than that in control group （P 〈 0.01 ）. Gensini score was significantly higher in AMI group than that in UAP group （P 〈 0.01 ）. The level of hs-CRP was positively related with Gensini score in ACS patients （r = 0.722 ,P 〈 0.01 ）. Conclusion Serum levels of high sensitive C-reactive protein in patients with ACS is closely related to the atherosclerostic lesions of coronary arteries, which suggests that hs-CRP may be an indicator to evaluate the severity of ACS.