猕猴注射肾上腺素后机体的生理生化改变

Physiological and biochemical changes in Rhesus monkeys after injection of adrenaline

目的探究恒河猕猴注射0.25mg/kg的肾上腺素后机体的生理生化改变。方法对16只恒河猕猴皮下注射0.25mg/kg肾上腺素,观察其心肺复苏情况;对存活的14只恒河猕猴,将其注射前及注射后0.5、1.0、3.0、5.0h血糖(Glu)、超敏C反应蛋白(hs-CRP)含量进行测定,并进行相关性分析。结果 (1)16只恒河猕猴中14只心肺复苏成功,2只死亡;(2)14只存活的恒河猕猴注射后各个时间段的Glu与注射前比较,差异有统计学意义(P<0.05);(3)注射后0.5、1.0、3.0、5.0hGlu值两两比较,差异无统计学意义(P>0.05);(4)14只存活的恒河猕猴注射后各个时间段的hs-CRP与注射前比较,差异有统计学意义(P<0.05);(5)注射后0.5、1.0、3.0、5.0hhs-CRP值两两比较,差异均无统计学意义(P>0.05);(6)14只存活的恒河猕猴注射0.25mg/kg肾上腺素后任意时间段的Glu和hs-CRP之间差异无统计学意义(P>0.05)。结论恒河猕猴注射0.25mg/kg肾上腺素后,有利于心肺复苏;恒河猕猴注射0.25mg/kg肾上腺素后,Glu值明显升高,但不致于发生全身性炎症反应综合征。

Objective To explore the changes in Rhesus monkey after injection of 0.25 mg/kg of adrenaline. Methods The situation of cardiopulmonary resuscitation of 16 Rhesus monkeys after subcutaneous injection of 0.25 mg/kg of adrenaline was observed, and glucose （Glu） and high-sensitive C reaction protein （hs-CRP） were detected in 14 survival Rhesus monkeys before injection and 0.5, 1.0, 3.0, 5.0 h after injection, and the correlation analysis was performed. Results （1） In 16 Rhesus monkeys, 14 cases were with successful cardiopulmonary resuscitation and 2 cases were dead. （2） In the 14 survival Rhesus monkeys, Glu levels detected before and after injection were with significant difference（P〈0.05）. （3） After injection, the 0.5, 1.0, 3.0 and 5.0 h Glu levels were without sta- tistically signifieance（P〉0.05）, compared each other. （4） In the 14 survival Rhesus monkeys, hs-CRP levels detec- ted before and after injection were with significant difference（P〈0.05）. （5） After injection, the 0.5, 1.0, 3.0 and 5.0 h hs-CRP levels were without statistical difference（P〉0.05）, compared each other. （6） In the 14 survival Rhesus monkeys, there did not exist significant correlation between Glu and hs-CRP at any time points（P〉0.05）. Con- clusion Injection of 0.25 mg/kg adrenaline might be useful for cardiopulmonary resuscitation in Rhesus monkeys, Injection of 0.25 mg/kg adrenaline could increase Glu level, but would not induce inflammatory response syndrome.