羊毛硫抗生素的研究进展及其应用

Research Progress and Applications of Lantibiotics

抗生素耐药性病原体在全球范围内的出现使得目前大多数使用的抗生素失去了原有的治疗效果,这就迫使人们急切需要开发出新的抗菌药物。羊毛硫抗生素(Lantibiotics)是革兰阳性菌通过核糖体合成机制产生的一类抗菌肽,可抑制微生物尤其是革兰阳性菌株的生长,有望可以代替传统抗生素控制耐药性病原菌。本文根据目前羊毛硫抗生素的研究,对羊毛硫抗生素的分类,作用机制和耐药性以及羊毛硫抗生素生物工程和应用进展进行了综述,并简单介绍了与羊毛硫抗生素相关的细菌素数据库。

Most currently used antibiotics are losing their original effect due to the emergence of antibiotic- resistant pathogens over the world. Thus, there is pressing need for the development of novel antimicrobial agents. Lantibiotics are ribosomally synthesized antibacterial peptides produced by Gram-positive bacteria. They can inhibit the growth of microbes, particularly Gram-positive bacteria. So lantibiotics are expected to be alternative drugs to control drug- resistant pathogens. This review provides an overview of the currently researches on lantibiotics, including lantibiotics＇ classification, mechanism of action, drug resistance, bioengineering, and their applications, and also provides a brief introduction to bacteriocins database related to lantibiotics.