热休克蛋白在男性不育中的研究进展

Heat shock protein in male infertility: Advances in studies

热休克蛋白是一类生物进化上高度保守的伴侣蛋白分子,具有多种生物学功能,包括作为分子伴侣、细胞保护、抗凋亡和免疫调节等。近年来研究发现,多种热休克蛋白参与精子发生、精子获能及受精等一系列活动,与男性生殖过程密切相关。因此,进一步研究热休克蛋白在男性不育中的具体机制及作用,可能为男性不育提供新的治疗途径。本文重点对热休克蛋白在男性不育中的研究进展作一综述。

Heat shock protein （HSP） is a group of evolutionarily highly conserved cell chaperone proteins involved in the processes of molecular chaperone, cytoprotection, anti-apoptosis and immunoregulation. Recent studies found that HSP is also involved in spermatogenesis, sperm capacitation and fertilization, which play a significant role in male reproduction. Therefore, further studies on the action mechanisms of HSP in male infertility may offer a new insight into the management of the problem.