摘要
目的:探讨结直肠癌组织中CD147和CK20的表达情况及其与结直肠癌临床病理特征的关系。方法:应用免疫组化技术检测60例结直肠癌组织中CD147和CK20的表达情况。结果:CD147、CK20在结直肠癌组织中的阳性表达率分别是86.7%、88.0%,CD147的表达可能与结直肠癌的淋巴结转移相关;CK20的表达可能与淋巴结转移和浸润程度相关。结论:结直肠癌组织中,CD147和CK20表达可能与结直肠癌的淋巴结转移相关,但二者无明显相关;联合检测结直肠癌组织中CD147和CK20的表达,可提高结直肠癌的病理诊断价值,对指导临床治疗及预后评估有重要意义。
Objective:To investigate the expression of CD147 and CK20 in colorectal carcinoma and their correlation with clinicopathological features. Methods: method was used to detect the expression of CD147 and CK20 in 60 cases of colorectal carcinoma. Results:The expression rates of CD147 and CK20 were 86.7% ,88.0%, respectively. The CD147 expression was negatively correlated with CK20 expression. There was a possible relationship between CD147 expression and lymph node. The CK20 expression was related with lymph node and invasion depth. Conclusion:In coloreetal carcinoma,the expression of CD147 and CK20 was related with lymph node, but they are in a negative correlation. The examination of both these two factors together is useful for predicting the invasion and metastasis of colorectal carcinoma, therefore, can be used as a significant marker to direct clinic therapy and estimation of prognosis.
出处
《现代肿瘤医学》
CAS
2013年第5期1062-1065,共4页
Journal of Modern Oncology
基金
兰州军区医药卫生科研计划课题(编号:LXH2008032)