KIF4A与肿瘤关系的研究进展

Recent advances in understanding the relationship between kinesin family member 4A and tumors

有丝分裂是细胞增殖的主要方式,并由多个基因共同调控完成。而这些调控基因的失衡可导致染色体非整倍性及肿瘤的形成。KIF4A是新近发现的驱动蛋白家族成员之一,其在染色体的浓缩与分离、纺锤体的形成及细胞质的分裂中发挥着重要作用。其作用的增强可引起有丝分裂活跃而导致细胞过度增殖,而其作用减低又可引起染色体不分离、染色体非整倍性和多倍体的形成,进一步导致肿瘤的形成。KIF4A在不同肿瘤中的表达及其与临床病理参数之间的关系具有差异性。通过探讨KIF4A与肿瘤之间的关系可为肿瘤早期诊断、治疗和预后评估提供帮助。

Mitosis is the main way of somatic cell proliferation, and this procedure is regulated by multiple genes. The imbalance of these gene functions might lead to chromosome instability and tumor formation. KIF4A is a recently identified kinesin family member,with significant role in chromosome condensation and segregation, spindle organization and cytokinesis. KIF4A depletion can result in chromosome mis - segregation, aneuploidy and polyploidy, consequently prompts tumor formation. And the enhancement of its function can lead to increased cell proliferation. The correlation of the expression of KIF4A with clinic pathological features in different cancers is not identical. Studying the relationship between KIF4A and tumor formation may offer help for early diagnosis, therapy and prediction prognosis.