性别、年龄、BMI对高血压患者动脉僵硬度的影响

Influences of gender, age, and body mass index on the arterial stiffness in hypertensive patients

目的探讨性别、年龄、BMI对高血压患者动脉僵硬度的影响。方法从上海市宝山区6家社区卫生中心及上海市第三人民医院入选1026例单纯高血压患者，收集病史信息，检测其颈一股动脉脉搏波速度（C—FPwV）。672例患者在随访一年后完成复测。从性别、年龄、BMI的不同水平进行分组比较及随访前后对照分析。结果（1）男性组C—FPwV高于女性组，分别为（13．63±3．07）m／s和（12．59±2．85）m／s（P〈0．01）。一年后两组C—FPwV均增快，男性为（14．11±3．58）m／s，女性（13．51±3．56）m／s（P〈0．05）。（2）30～50岁、〉50～70岁、〉70岁三组C—FPWV随年龄增大而增快，分别为（11．11±2．00）m／s、（12．73±2．77）m／s、（14．74±3．29）m／s（P〈0．01）。1年后3组的C—FPwV均增快，分别为（11．36±1．78）m／s（P〉0．05）、（13．39±3．33）m／s（P〈0．01）和（15．68±3．94）m／s（P〈0．05），C-FPwV增幅依次为：〉70岁组、〉50～70岁组、30～50岁组。（3）BMI／〉24krJm。组较BMI〈24kg／m。组C—FPwV略低，分别为（12．93±2．89）m／s和（13．39±3．18）m／s（P〈0．05）。1年后C—FPwV值均有增高，分别为（13．54±3．54）m／s，（14．27±3．61）m／s（P〈0．01）。结论除BMI外，性别、年龄均为动脉僵硬度的重要影响因素。

Objective To investigate the influences of gender, age, and body mass index （BMI） on the arterial stiffness in hypertensive patients. Methods A total of 1026 hypertensive patients were en- rolled in this study from 6 community health centers in Baoshan District and Shanghai Third People~ Hospi- tal. The Related medical histories and carotid-femoral（C-F） pulse wave velocity （PWV） were recorded and PWV were re-tested in 672 patients after 1 yearg follow-up. The C-F PWV was analyzed from different group of Gender, age and BMI at baseline and after follow up. Results （1）C-F PWV of the male hypertensive pa- tients were higher than that of female＇s and the corresponding figures were （13.63 ± 3.07 ）m/s and （12. 59 ±2. 85）m/s（ P 〈 0. 0） ）. After one year% follow up, C-F PWV was increased in both male and female with corresponding figures of （ 14. 11 ±3.58）m/s and （ 13.51 ±3.56）m/s（ P 〈0. 05）. （2） The C-F PWV was increased with age. The corresponding figures were [ （ 11.11 ± 2. 00） m/s for age group 30 - 50 years old, （12.73 ±2.77）m/s for age group 〉50 -70 years old, and （14.74 ±3.29）m/s for age group 〉70 years old, all P 〈 0. O1 ]. After one year＇s follow-up, C-F PWV of three age groups was increased and the corresponding figures were [（11.36 ±l.78）m/s（P 〉0.05）, （13.39 ±3.33）m/s（ P 〈0.01）, and （ 15.68 ±3.94）m/s（ P 〈0. 05） ]. The increased range of C-F PWV （from high to low） was age group 〉 70, age group 〉 50 -70 and age group 30 -50. （3） C-F PWV of patients with BMI ≥24 kg/m2 was signifi- cantly lower than that of patients with BMI 〈 24 kg/m2 and the corresponding figures were [ （ 12. 93 ± 2. 89 ） m/s and （ 13.39 ± 3.18 ） m/s, P 〈 0.05 ]. After one yearg follow up, C-F PWV was increased and the fig-ures were [（13.54±3.54）m/sand （14.27±3.61） m/s, respectively（ P 〈0.01）]. Conclusions Ex- cept BMI, gender and age were the important influence factors on arterial stiffness.