中药外用洗剂妇洗液的药效学研究

The Pharmacodynamic Research on Fuxiye, a Chinese Herbal Lotion for External Wash

目的观察中药外用洗剂妇洗液的抗菌、抗肿胀和治疗阴道炎模型大鼠的作用。方法采用琼脂平板扩散法、二甲苯致小鼠耳廓肿胀法和化学刺激导致的大鼠宫颈炎模型,观察中药外用洗剂妇洗液的体外抗菌作用,以及对模型动物的肿胀、炎症的影响程度。结果中药外用洗剂妇洗液在25mg/mL浓度下能完全抑制铜绿假单胞菌、大肠埃希菌、化脓性链球菌和无乳链球菌;在50mg/mL浓度下能完全抑制金黄色葡萄球菌和白色念珠菌;对二甲苯所致的小鼠耳廓肿胀有明显的抑制作用;能有效的改善化学因素刺激所引起的大鼠阴道炎。结论中药外用洗剂妇洗液具有较好的抗菌、消炎和治疗阴道炎的作用。

Objective To observe antisepsis, anti-swelling, and therapeutic effects of Fuxiye （FXY）, a Chinese medical lotion for external wash in treating vaginitis model rats. Methods The cervicitis rat model was induced by agar plate diffusion, ear auricle swelling induced by dimethylbenzene, and chemical stimulus. The in vitro antibiotic actions of FXY were observed. Besides, its effects on the swelling and inflammation in model rats were also observed. Results FXY at 25 mg/mL could completely inhibit the growth of Pseudomonas aeruginosa , Escherichia coli , pyogenic streptococcus , and streptococcus agalactiae . FXY at 50 mg/mL could completely inhibit the growth of Staphylococcus aureus and Candida albicans . It obviously restrained dimethylbenzene induced ear auricle swelling. It significantly alleviated cervicitis induced by chemical stiumli. Conclusion FXY showed better effects on antisepsis, anti-inflammation, and treating cervicitis.