还原型谷胱甘肽对梗阻性肾病肾损伤保护作用的观察

Protective effects of reduced glutathione on obstructive nephropathy

目的:观察还原型谷胱甘肽对梗阻性肾病所致肾损伤的保护作用。方法:收集我院2010年1月至2011年12月42例梗阻性肾病所致肾损伤的患者,随机分为还原型谷胱甘肽治疗组(n=24)和对照组(n=18)。治疗组在常规治疗的基础上给予还原型谷胱甘肽1 800 mg静脉滴注,每日1次,共治疗14d;对照组仅给予常规治疗。比较两组治疗前、后血肌酐、尿素氮、SOD及尿液β_2-MG、NAG水平。结果:治疗后还原型谷胱甘肽治疗组[(62.9±20.3)μmol/L,(5.7±1.88)mmol/L,(0.35±0.10)mg/L,(10.59±3.55)U/L]较对照组[(109.1±29.6)μmol/L,(7.2±2.23)mmol/L,(0.80±0.26)mg/L,(25.21±7.56)U/L,P<0.05]下降更明显,血清SOD水平明显高于对照组[(399.09±105.42)u/mL vs(257.96±81.15)U/mL.P<0.01]。结论:还原型谷胱甘肽可以减少梗阻性肾病患者肾脏的氧化应激性损伤,有助于肾小球和肾小管功能的恢复。

Objective： To investigate the protective effects of reduced glutathione on obstructive nephropathy-induced renal injury. Methods ： Forty-two patients with obstructive nephropathy were recruited from the First Affiliated Hospital of Guangzhou Medical College, between January 2010 and December 2011, and were randomly assigned to be treated with conventional therapy alone （control group, n = 18 ） or in combination with 14-day intravenous reduced glutathione 1800rag once daily （treatment group, n = 24）. The levels of serum creatinine （Cr） , blood urea nitrogen （BUN） , superoxide dismutase （SOD） and urinary β2-microglobin （ β2- MG） and NAG were compared prior to and after treatment. Results： Treatment with reduced glutathione resulted in marked reduced serum Cr [ （ 62.9 ± 20.3 ）μmol/L vs. （ 109.1 ± 29.6）μmoL/L] , BUN [ （ 5.7 ± 1.88 ） retooL/ Lvs. （7.2±2.23）mmol/L] and urine β2-MG[ （0.35 ±0. 10）mg/Lvs. （0.80±0.26）mg/L]and NAG [（10.59± 3. 55）U/L vs. （25. 21 ±7. 56） U/L ] when compared with control group （all P 〈0. 05） yet significantly higher level of SOD [ （ 399.09 ± 105.42 ） U/mL vs. （ 257.96± 81. 15 ） ] U/mL, P 〈 0.01 ）. Conclusion ： Reduced glutathione may contribute to the recovery of glomerular and tubular function by attenuating oxidative stress-induced in patients with obstructive nephropathy.