慢性阻塞性肺疾病合并2型糖尿病患者凝血、纤溶功能的变化

The changes of blood coagulaion and fibrinolysis in patients of Chronic obstructive pulmonary disease with type 2 diabetes

目的通过对慢性阻塞性肺疾病(COPD)合并2型糖尿病(T2DM)患者血浆D-二聚体(D-D)、纤维蛋白(FIB)的检测,探讨COPD合并T2DM患者凝血、纤溶功能的变化。方法分组:单纯COPD组(30例),有并发症组(30例)和无并发症组(30例)。分别检测各组血浆D-D、FIB的含量。采用SPSS17.0统计学软件,分别对各组的D-D、FIB进行比较。结果有并发症组的D-D、FIB均高于单纯COPD组及无并发症组,差异均有统计学意义(P<0.01),无并发症组的D-D、FIB与单纯COPD的比较差异无统计学意义(P>0.05)。结论 CDPD合并T2DM患者伴有视网膜、肾和周围神经病变等微血管病变时,进一步加重患者的凝血、纤维功能紊乱。在诊治COPD合并T2DM并发症患者时,要充分考虑到患者存在的凝血纤溶功能异常,注意监测相关凝血纤溶指标,对防治COPD有重要意义。

Objective Investigate changing of Coagulation, fibrinolysis in Chronic obstructive pulmonary disease （COPD） with type 2 diabetes（T2DM） patients by detecting plasma D-dimer（D-D） ,fibrin（FIB）. Methods Group：pure COPD group（30 cases）;Complications group（30 cases） ;Non-complication group（30 cases）. Measuring DD and FIB in plasma of each group. Using statistical software SPSS17.0. Separately for each group of D-D, FIB comparison. Results D-D.FIB in Complications groups was higher than COPD group Differences were statistically significant（P〈0.01）; DD, FIB in Non-complication group compared with pure COPD, no statistically significant difference（P〉0.05）. Conclusion COPD patients with T2DM patients with retinal,renal,and peripheral neuropathy and other microvascular dis- ease,to further increase the patient＇s blood coagulation and fibrinolysis disorders. Complications in the treatment of pa tients with COPD with T2DM,we must fully take into account patients with abnormalities of coagulation and fibrinoly- sis,coagulation and fibrinolysis to pay attention to the relevant monitoring indicators, prevention and treatment of COPD is important.