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Clusterin在急性肾损伤诊断中的意义 被引量：6

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摘要 急性肾损伤在临床非常常见,其发病率和死亡率都很高,所以选择合适的生物标志物对早期肾损伤进行检测有着非常重要的意义。目前急性肾损伤中最常用的生物标志物仍为血肌酐（SCr）、尿素氮（BUN）,近年来一些新的生物标志物陆续被应用,如中性粒细胞相关载脂蛋白（NGAL）、胱抑素C（cystatin C）、肾脏损伤分子1（KIM-1）、白细胞介素18（IL-18）等,各有优缺点。本文介绍了一种新的肾损伤检测标志物丛集素（Clusterin）,主要介绍丛集素在检测急性肾损伤中所表现出来的敏感、快速与准确的特性。
作者 邹颖刚 王欢 耿嘉男 印悦 石艳 于晓艳
机构地区 吉林大学第二医院 吉林大学白求恩医学院 吉林大学药学院
出处 《中国实验诊断学》 2013年第5期982-982,F0003,共2页 Chinese Journal of Laboratory Diagnosis
基金 吉林省科技发展计划资助项目(科技支撑计划20120962) 吉林大学科学前沿与交叉学科创新项目(201103233)
关键词 急性肾损伤 CLUSTERIN 生物标志物 诊断 损伤检测 早期肾损伤 中性粒细胞 白细胞介素
分类号 R692 [医药卫生—泌尿科学]
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参考文献16

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  • 2Murphy BF,Kirszbaum I.,Walker ID,et aI. SP 40,40,a newly i dentil'led normal human serum protein found in the SCSb 9 corn plex of complement and in the immune deposits in glomerulone phritis[J]. J Clin Invest, 1988,81(6) : 1858.
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二级参考文献15

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  • 7Rosenberg M E, Dvergsten J, Correa-Rotter R. Clusterin: an enigmatic protein recruited by diverse stimuli[J]. J Lab Clin Med,1993,121(2):205-214
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共引文献1

同被引文献47

  • 1姜毅,贾金康.尿IL-18水平对急性肾衰竭的早期诊断作用[J].国际泌尿系统杂志,2006,26(4):560-562. 被引量：2
  • 2Prochnow H, Gollan R, Rohne P, et al. Non Secreted Clusterin Isoforms Are Translated in Rare Amounts from Distinct Human mRNA Variants and Do Not Affect Bax-Mediated Apoptosis or the NF-κB Signaling Pathway[J]. PloS one,2013,8(9) :e75303.
  • 3Murphy BF,Kirszbaum L,Walker ID,et al. SP-40,40,a newly identified normal human serum protein found in the SC56-9 complex of complement and in the immune deposits in glomerulone phritis[J]. J Clin Invest, 1988,81 (6) :1858.
  • 4Rosenberg M E, Dvergsten J, Correa-Rotter R. Clusterin : an enig matic protein recruited by diverse stimuli [J]. J Lab Clin Med, 1993,121(2) :205.
  • 5吴丹.肾小管上皮细胞表型转化与移植肾纤维化的相关性[D].吉林大学,2013.
  • 6Crowley S T, Peixoto A J. Acute kidney injury in the intensive care unit[J]. Clinics in chest medicine, 2009,30 ( 1 ) : 29.
  • 7Schiffl H, Lang SM, Fischer R. Daily hemodialysis and the outcome of acute renal failure[J]. N Eng J Med,2002,346 (2) :305-310.
  • 8Parikh CR,Devarajan P. New biomarkers of acute kidney injury[J]. Crit Care Med,2008,36(S4) : 159-165.
  • 9Che M,Xie B,Xue S,et al. Clinical usefulness of novel bi- omarkers for the detection of acute kidney injury follow- ing elective cardiac surgery[J]. Nephron Clin Pract, 2010, 115(1) :66-72.
  • 10Parikh CR,Jani A, Melnikov VY, et al. Urinary interleu- kin-18 is a marker of human acute tubular necrosis[J]. Am J Kidney Dis,2004,43(3) :405-414.

引证文献6

二级引证文献20

中国实验诊断学
2013年 第5期

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