1横田慎一 熊毅雄治 内海光朝.A Pharmacokinetic Study of MCI—186,a novel drug for cerebrovascular disease in elderly and young healthy subjects[J].临床药理,1997,28(3):693-702.
2Mizuno A,Umemura K,Nakashima M.Inhibitory effect MCI-186,a free radical scavenger,on cerebral ischemia following rat middle cerebral artery occlusion[J].Gen Pharmacol,1998,30(4)∶575-578.
3Kawai H,Nakai H,Misao S,et al.Effects of a novel free radical scavenger,MCI-186,on ischemic brain damage in the rat distal middle cerebral artery occlusion model[J].J Pharmacol Exp Ther,1997,281(2)∶921-927.
5Yamamoto T,Yuki S,Watanabe T,et al.Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia[J].Brain Res,1997,762(12)∶240-242.
6Watanabe T,Egawa M.Effects of an antistroke agent MCI-186 on cerebral arachidonate cascades[J].J Pharmacol Exp Ther,1994,271(3)∶1624-1629.
7Watanabe T,Morita I,Nishi H,et al.Preventive effect of MCI-186 on 15-HPETE induced vascular endothelial cell injury in vitro[J].Prostaglandins Leukotrienes Essent Fatty Acids,1998,33(1)∶81-87.
8Mitsumori K,Sakuragi M,Kitami K,et al.The effect MCI-186 on regional cerebral blood flow in patients with acute cerebral infarction-A sequential SPECT study[J].Ther Res,1998,19(4)∶1333-1345.
9山本美奈子 高松康雄.Pharmacokinetic studies of 3—methyl—1—phenyl—2—pyrazolin—5—one（MCI—186）：protein binding and distribution to red blood cell[J].药理と治疗,1997,25(17):1755-1763.
6Kuner LH. Dementia epidemiology research: it is time to modify the focus of research[J]. J Gerontol A Biol Sci Med Sci, 2006, 61(12): 1314 -1318.
7Vaughan L, Bushnell C, Bell CL, et al. Global cognitive function before, surrounding, and after isehemic stroke: the role of risk and protective factors varies with time among ischemic stroke survi- vors[J]. Aging Neuropscychology and Cognition, 2015, Doi: 10. 1080/13825585. 2015. 1058323.
8Abmad A, Khan MM, Javed H, et al. Edaravone ameliorates oxi- dative stress associated eholinergic dysfunction and limits apoptotic response following focal cerebral ischemia in rat[ J]. Mol Cell Bio- ehem, 2012, 367(1-2): 215-225.
9Ishibashi A, Yoshitake Y, Adachi H. Investigation of effect of edaravone on ischemic stroke[ J]. Kurume Med J, 2013,60(2) : 53 -57.
10Wada T, Yasunaga H, Inokuchi R, et al. Effects of edaravone on early outcomes in acute ischemic stroke patients treated with re- combinant tissue plasminogen activator[ J ]. J Neurol Sci, 2014, 345(1-2) : 106 -111.
