高迁移率族蛋白B1在缺血/再灌注损伤中的研究进展

Research Progress of High Mobility Group Box 1 in Ischemia/Reperfusion Injury

高迁移率族蛋白B1(HMGB1)是一类进化高度保守的DNA结合蛋白,广泛存在于真核细胞内。HMGB1可通过活化细胞的主动分泌或细胞坏死、损伤等被动释放至细胞外,通过与Toll样受体、晚期糖基化终末产物受体等结合,激活相应的信号转导通路,参与多种疾病的发生、发展。近年来研究显示,细胞外的HMGB1作为炎性介质在组织器官缺血损伤或缺血/再灌注损伤(IRI)中发挥重要作用,对HMGB1的干预治疗有可能成为防治IRI的新靶标。

High mobility group box 1 （HMGB1） is a highly conservative DNA-binding protein which widely presents in eukaryotic cells. It can either be actively secreted into the extracellular milieu by activated cells or passively released by necrotic of damaged cells. Through binding with cell-surface receptors such as Toll-like receptors and receptor of advanced glycation endproduets（RAGE） ,HMGBI can activate the corresponding signal transduction pathway and contribute to the pathogenesis of diverse disorders. Recently,many reports show that, extracellular HMGB1, as an inflammatory medium, plays an important role in ischemia/ rePerfusion injury of tissues and organs. Targeting HMGB1 may provide a novel therapeutic approach for prevention of ischemia-reperfusion injury.