肌腱修复的组织工程研究进展

Research Advances in Tissue Engineering of Tendon Repair

对于肌腱缺损,传统的手术方法虽然可以减轻患者的痛苦,但是其功能重建并不乐观。随着肌腱组织工程的发展,用工程化肌腱来修复肌腱缺损正在成为一个新兴的治疗方法。目前,组织工程肌腱的研究涉及种子细胞、支架、生长因子和改进策略等各方面。组织工程化肌腱临床应用的关键是如何模拟体内环境,在体外成功构建肌腱组织。因此,在体外模拟体内环境进行组织工程的构建是未来的研究方向之一。

Though the traditional operative therapy for tendon lesion can relieve the suffering of patients, the functional reconstruction is usually not optimistic. As the development of tissue-engineering tendon using engineered tendon to repair tendon lesion is becoming a new therapeutic method. Currently the achievements in the areas of tendon tissue engineering research include the seed ceils, scaffolds, growth factors and improvement for the tissue-engineering tendon. The key of tissue-engineered tendon in practical clinical application is how to simulate body environment to construct tendon tissue in vitro. Therefore simulating in vivo environment and construction of tissue engineering in vitro is one of future research directions.