摘要
Wnt信号通路参与细胞的分化、增殖和凋亡,并在多种肿瘤的发生、发展中起着重要作用。Dapper是一类新发现的信号调控分子家族,是散乱蛋白Dishevelled的相互作用蛋白,而散乱蛋白是Wnt信号通路中关键性的正向调控因子。多发性骨髓瘤(MM)的发病机制复杂,在分子生物学上需要许多信号通路参与。该文就Dapper的生物学特性及其在MM发生、发展中的作用研究进行阐述。
Wnt signaling pathway takes part in cells＇ differentiation, proliferation and apoptosis, and plays an important role in many tumors＇ genesis and development. Dapper is a newly discovered family of sig- nal regulatory molecule, as Dishevelled-interacting regulators of Wnt signaling pathway, while Dishevelled is an important positive regulator of Wnt signal pathway. The mehanism of multiple myeloma is complicated, which includes lots of signal pathways. Here is to make a review on the biological characteristics of Dapper, and its roles in the formation and develonment of multinle mveloma.
出处
《医学综述》
2013年第9期1589-1591,共3页
Medical Recapitulate
