分泌性中耳炎的形成机制与鼻咽癌放疗的相关性及治疗进展

Formation Mechanism of Secretory Otitis Media and Its Correlation with Nasopharyngeal Carcinoma and Radiotherapy,and the Treatment Progress

分泌性中耳炎(SOM)是耳鼻咽喉科常见疾病,以鼓室积液和传导性聋为主要特征,属于中耳非化脓性炎。近年来大量的临床研究显示,SOM的形成是咽鼓管功能障碍、乳突气化不良、感染、变态反应、细胞因子等多种因素相互作用的结果,而与鼻咽癌及放疗有关的SOM的发病机制更为复杂,预后欠佳。在此,对近年来SOM及与鼻咽癌和放疗有关的主要发病机制及治疗现状进行综述。

With ear effusion and conductive deafness as the main feature, secretory otitis media （ SOM ） is a common disease of otolaryngology. SOM is the middle ear non-suppurative inflammation. In recent years, a large number of clinical studies have shown that the formation of SOM is due to the eustachian tube dysfunction, poor pneumatization of mastoid, infection, allergy, cytokines and other factors. The pathogenesis of the SOM induced by nasopharyngeal carcinoma（NPC） and radiotherapy is more complex and the prognosis is poor. Here is to make a review on the main pathogenesis and treatment of the SOM induced by NPC and radio therapy in recent years.