酮替芬联合舒利迭治疗哮喘合并变应性鼻炎的疗效观察

The curative effect of ketotifen in combination with inhaled seretide in treating bronchial asthma and allergic rhinitis

目的观察酮替芬联合舒利迭治疗支气管哮喘合并变应性鼻炎的临床疗效。方法 62例支气管哮喘合并变应性鼻炎随机分为两组,观察组32例口服酮替芬1mg,每天2次,对照组30例口服孟鲁司特钠10mg每天1次,两组同时吸入舒利迭50/250μg,每天2次,治疗时间12周。结果两组治疗后与治疗前的哮喘控制测试评分(ACT)和FEV1和PEF、变应性鼻炎的症状评分比较差异有统计学意义(P<0.01),观察组与对照组的ACT比较差异有统计学意义(P<0.05),变应性鼻炎的症状评分,观察组与对照组比较差异有统计学意义(P<0.05)。结论酮替芬联合舒利迭治疗哮喘合并变应性鼻炎时在改善FEV1和PEF方面不差于孟鲁司特钠联合舒利迭,在提高ACT和改善变应性鼻炎的症状评分方面好于孟鲁司特钠联合舒利迭。

Objective To evaluate the therapeutic effect of ketotifen in combination with inhaled seretide in treating bronchial asthma and allergic rhinitis. Methods Divided 62 asthma and allergic rhinitis cases into 2 groups randomly. The control group was treated with seretide 1 mg twice daily via accuhaler, while the group was added montelukast sodium 10 mg evertime one daily. The observation group was treated with seretide 50/250 μg twice daily via accuhaler , while the group was added ketoti{en tablet ling everytime twice daily, for 12-week treatment study was conducted. Results The observation group was significantly higher than the control group on the score of the asthma control test（ACT）（P〈0.05） . The observation group was significantly lower than the control group on the symptomatic score of allergic rhinitis（P〈0.05）. Conclusion The treatment effect of ketotifen in combina-tion with inhaled seretide was better than that of montelukast sodium in combination with inhaled seretide in improving the score of ACT and in reducing the symptoms score of allergic rhinitis.