摘要
目的利用临床分离株耐甲氧西林金黄色葡萄球菌(MRSA)菌株感染BALB/c小鼠,建立小鼠的血流感染模型,再用该模型比较利奈唑胺与万古霉素对感染小鼠的治疗效果。方法分别对MRSA感染组、利奈唑胺治疗组和万古霉素治疗组小鼠的临床症状、生存时间曲线和血液中的细菌计数进行时相性的观察和检测。结果 MRSA感染组小鼠的生存率明显低于利奈唑胺治疗组和万古霉素治疗组,且利奈唑胺治疗组要高于万古霉素治疗组,但二者之间差异无统计学意义。另外,MRSA感染组小鼠血液中的菌量较高,而在利奈唑胺治疗组或万古霉素治疗组血液中的菌量明显减少,但二者之间差异无统计学意义(P>0.05)。结论利奈唑胺和万古霉素治疗小鼠MRSA血流感染的疗效基本相当。
Objective To established a bacteriemia model of BALB/c mice after infection with clinical methicillin-resistant staph-ylococcus aureus(MRSA) strain and then evaluated by linearly versus vancomycin in the treatment of MRSA experimental bacterae-mia. Methods We monitored the clinical signs, gross observations of MRSA infected mice,vancomycimtreated mice and linezolid-treated mice and counted the bacteria in blood among different groups. Results The survival rate in MRSA infected group was sig- nificantly lower than that in vancomycin-treated group or linezolid-treated group. The survival rate in linezolid-treated group was higher than that in vancomycin-treated group, however, there was no significant difference between them. Otherwise, bacterial blood concentrations was higher in MRSA infected group,but there was no significant difference between linezolid-treated group and van-comycin-treated group. Conclusion The efficacy of linezolid versus vaneomycin regimens against the MRSA isolate is not statisti-cally different,although both treatments are significantly different from MRSA infected group.
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第16期1844-1845,1848,共3页
Chongqing medicine