燃煤型氟中毒儿童及成人血锌含量分析

Analyses of the content of blood zinc in children and adults from coal-burning endemic fluorosis ward

目的了解燃煤污染型地方性氟中毒(以下简称燃煤型氟中毒)人群血锌(Zn)含量的变化情况。方法采取分层整群随机抽样方法,抽取重庆市巫山、奉节2个燃煤型氟中毒病区县作为调查点,在两县各抽取50例氟斑牙患者及100名健康对照者以及在巫山县抽取30例氟骨症患者及60名健康对照者组成样本。对390名研究对象抽取空腹静脉血并测定血Zn含量,收集尿液并检测尿氟含量。t检验对比分析病例与对照者血Zn、尿氟含量的差异以及两县人群之间血Zn、尿氟含量的差异。结果两县儿童及巫山成人尿氟平均含量均为病例组高于对照组(P<0.05)。巫山儿童和成人血Zn含量以及奉节儿童血Zn含量均为病例组低于对照组(P<0.05)。巫山儿童病例组和对照组血Zn含量分别低于奉节儿童病例组和对照组血Zn含量(P<0.05)。结论燃煤型氟中毒引起人体血Zn含量下降;该病防治效果较差的巫山人群血Zn含量普遍较低。

Objective To investigate the concentration of blood zinc（Zn）in people who live in the coal-burning endemic fluorosis （the following referred to as coal-burning fluorosis） ward. Methods Take the stratified cluster random .sampling method,Wushan County and Fengjie County,in the coal-burning endemic fluorosis ward in Chongqing Northeast region,were selected as the survey point. 150 children（50 with dental fluorosis, 100 healthy controls） and 90 adults（30 with skeletal fluorosis, 60 healthy controls） were selected from Wushan County and 150 children（50 with dental fluorosis, 100 healthy controls） were selected from Fengjie County formed the samples. Fasting venous blood samples were collected by venipuncture in vacuum tubes from the 390 subjects and examined for the concentration of blood Zn, Spot urine samples were also collected from them and the fluoride levels were detec-ted. Blood Zn levels and urinary fluoride between cases and controls who came from the same county were analyzed by t-test, and blood Zn levels and urinary fluoride between cases and cases,controls and controls who came from different counties were also ana-lyzed by t-test. Results The average content of urine fluorine of case groups were higher than those of control groups in both chil- dren and adults（P〈0.05）. The concentration of childrenrs blood Zn and adult blood Zn were significantly lower in fluorosis pa-tients than in controls in Wushan County; The concentration of children/s blood Zn was significantly lower in fluorosis patients than in controls in Fengjie County（P〈0.05）. The concentration of blood Zn of cases and controls of Wushan children were lower than cases and controls of Fengjie,respectively（P〈0.05）. Conclusion Coal-burning fluorosis causes the concentration of blood Zn de- creased, The concentration of blood Zn is generally lower of people in Wushan County where the measures taken to prevent the coal- burning fluorosis were ineffective.