胸部创伤患者早期SIRS评分及血清中C反应蛋白含量与创伤后感染的关系

Systemic Inflammatory Response Syndrome Score and Serum Level of C-reactive Protein in Prediction of Post-Traumatic Infection in Patients with Thoracic Trauma

目的:研究胸部创伤患者早期的全身炎性反应综合征(systemic inflammatory response syndrome,SIRS)评分及血清C反应蛋白(C-reactive protein,CRP)含量与创伤后感染的关系。方法:选取复旦大学附属上海市第五人民医院胸外科2009年7月—2012年6月收治的以胸部创伤为主的患者406例,入院时均进行SIRS评分,检测伤后24 h血清CRP含量。分析SIRS评分和血清CRP含量与创伤后感染的关系。结果:SIRS评分3～4分患者创伤后感染发生率高于SIRS评分0～1分及2分患者。logistic回归显示,SIRS评分3～4分是胸部创伤患者发生创伤后感染的独立预测因素。感染组伤后24 h血清CRP含量显著高于非感染组。结论:入院后SIRS评分是预测胸部创伤患者发生创伤后感染的有效指标。创伤后24 h血清CRP含量的升高幅度对预测患者后期是否发生感染有一定参考价值。

Objective：To investigate whether systemic inflammatory response syndrome （SIRS） score can be used as predictor of post traumatic infection in chest trauma patients, and to study the relationship between serum level of （2reactive protein （CRP） and post-traumatic infection. Methods：A total of 406 patients with chest trauma and concomitant multiple injuries admitted in Shanghai Fifth People＇s Hospital, Fudan University from July 2009 to June 2012 were analyzed. SIRS score was calculated at admission for each patient. Serum level of CRP was observed 24 h after trauma. Results： Logistic regression analysis confirmed that SIRS score ≥3 at admission was a significant independent predictor of post-traumatic infection in chest trauma. Patients with post-traumatic infection showed higher CRP concentrations. Conclusions： Admission SIRS score is a predictor of post traumatic infection in chest trauma. CRP level at 24 h after trauma could be taken as a reference for later infectious complications.