胰腺癌与糖尿病的关系分析

Relationship between Pancreatic Cancer and Diabetes

目的:探讨糖尿病与胰腺癌之间的关系。方法:回顾分析181例胰腺癌患者的临床资料,根据是否合并糖尿病将其分为糖尿病组(DM组,n=65)和非糖尿病组(非DM组,n=116)。分析两组发病年龄、性别、肿瘤分化程度、肿瘤部位、术前指标、肿瘤免疫组化指标之间的差异。结果:两组年龄、性别、术前总胆红素、CA199、肿瘤分化程度、肿瘤部位差异无统计学意义。肿瘤免疫组化指标中,P53、CEA、S100在两组间差异无统计学意义;DM组Ki-67增殖指数>50%2例(5.13%),非DM组Ki-67增殖指数>50%12例(23.53%),Ki-67增殖指数在两组间差异有统计学意义(χ2=4.38,P<0.05)。结论:DM组Ki-67增殖指数较非DM组低,两组年龄、性别、肿瘤分化程度、肿瘤部位和生化指标差异无统计学意义。

Objective：To analyze the clinical features of patients with pancreatic cancer and diabetes. Methods： A total of 181 pancreatic cancer patients have been enrolled. Among them, 65 cases were also suffered from diabetes（DM group） while the other 116 cases were not（non-DM group）. Age, gender, tumor grade, tumor location, biochemical indicators and immunohistochemical markers were compared between the two groups. Results： There were no differences in age, gender, the level of bilirubin, the level of CA199, tumor grade and tumor location between the two groups. There were no differences in the levels of P53,CEA and S100 between the two groups. In DM group, the percent of patients with Ki-67〉50% was 5.13%, and in non-DM group the percent was 23.53 % ; the difference was significant（χ2 = 4.38,P〈0.05）. Conclusions： The Ki-67 in diabetes group was lower than that in non-DM group. There were no differences in age, gender, tumor grade, tumor location, biochemical indicators between the two groups.