期刊文献+

Müller细胞干细胞特性的研究进展

Current researches on stem cell-like function of retinal Miiller cells
原文传递
导出
摘要 视网膜退行性病变缺少有效的防治方法。研究显示,Muller细胞可表达视网膜神经元细胞标记物如钙视网膜蛋白、视黄醛结合蛋白等。人Muller细胞不但可表达神经干细胞相关转录因子如SOX2、PAX6、CHX10、NOTCHl,还表达视网膜神经元标记物如双极细胞标记物蛋白激酶C,光感受器神经元标记物(盘膜边缘蛋白),神经节细胞标记物HuD与Brn3,大部分神经元标记物神经丝蛋白、βⅢ微管蛋白,神经节细胞、无长突细胞和水平细胞阳性标记物(钙视网膜蛋白)。因此表明,视网膜Muller细胞可分化成不同视网膜神经元细胞,具有干细胞特性,利用Muller细胞进行细胞移植可能是治疗视网膜退行性病变具有潜力的新策略。 There is no effective clinical treatments for retinal nerve degenerative disease. Recent studies demonstrate that retinal Muller cells expressed neural stem cell markers including SOX2, PAX6, CHX10, NOTCH1 and βⅢ tubulin, as well as various markers of postmitotic retinal neurons, including PKC ( a marker of bipolar cells), peripherin ( a marker of photoreeeptor cells), HuD and Brn3 ( markers of ganglion cells), neurofilament protein ( a marker of ganglion, amacrine, and horizontal cells ), and calretinin ( a marker of ganglion, amacrine, and horizontal cells). These studies demonstrated that Mtiller cells exhibit progenitor characteristics and can differentiate to various retinal neurons, and suggested that Muller cells may have the potential for cell-based therapies for retinal nerve degenerative disease.
作者 陈丽英 姚进
出处 《国际眼科纵览》 2013年第2期123-128,共6页 International Review of Ophthalmology
基金 国家自然科学基金(81271028)
关键词 MULLER细胞 干细胞 视网膜退行性病变 细胞移植 Muller cell stem cell retinal nerve degenerative diseases cell transplantation
  • 相关文献

参考文献31

  • 1Hipp J, Atala A. Sources of stem cells for regenerative medicine, Stem Cell Rev, 2008, 4: I-3.
  • 2王培林,杨康娟,王振华,等.干细胞.见:王培林.医学细胞生物学.第二版.北京:人民卫生出版社,2010:258-275.
  • 3Distler C, Dreher Z. Glia cells of the monkey retina--ll. Mfiller cells. Vision Res, 1996, 36: 2381-2594.
  • 4Uga S, Smelser GK. Comparative study of the fine structure of ret- inal Mtiller cells in various vertebrates. Invest Ophthalmol, 1973, 12 : 434-448.
  • 5Newman EA. Voltage-dependent calcium and potassium channels in retinal glial cells. Nature, 1985, 317(6040) : 809-811.
  • 6Newman EA. Inward-rectifying potassium channels in retinal glial (Mfiller) cells. Neurosci, 1993, 13: 3333-3345.
  • 7Puro DG, Stuenkel EL. Thrombin-induced inhibition of potassium currents in human retinal glial (Mailer) cells. J Physi, 1995, 485 : 337-348.
  • 8Chao TI, Skaehkov SN, Eberhardt W, et al. Na+ channels of Mailer (glial) cells isolated from retinae of various mammalian species including man. Gila, 1994,10 : 173-185.
  • 9Kofuji P, Biedermann B, Siddharthan V, et al. Kir potassium- channel subunit expression in retinal glial cells: implications for spatial potassium buffering. Glia, 2002, 39: 292-303.
  • 10Kubo Y, Baldwin TJ, Jan YN, et al. Primary structure and func- tional expression of a mouse inward rectifier potassium channel. Nature, 1993, 362(6416) : 127-133.

二级参考文献22

  • 1李树宁,王竫华,白海青,王大博.改进的酶消化法培养新生大鼠Müller细胞[J].眼科研究,2005,23(2):155-157. 被引量:23
  • 2刘晓娟,惠延年,郭斌,张乐,郝晓凤.缺氧下外源性血管内皮生长因子对体外大鼠Müller细胞的影响[J].国际眼科杂志,2007,7(2):395-399. 被引量:5
  • 3Agathocleous M, Harris WA. 2009. From progenitors to differentiated cells in the vertebrate retina[J]. Ann Rev Cell Dev Biol, 25: 45-69.
  • 4Birnbach CD, Jarvelainen M, Possin DE, Milam AH. 1994. Histopathology and immunocytochemistry of the neurosensory retina in fundus flavimaculatus[J]. Ophthalmology, 101: 1211-1219.
  • 5Das AV, Mallya KB, Zhao X, Ahmad F, Bhattacharya S, Thoreson WB, Hegde GV, Ahmad I. 2006. Neural stem cell properties of Muller glia in the mammalian retina: regulation by Notch and Wnt signaling[J]. Dev Biol, 299: 283-302.
  • 6Fischer AJ, Reh TA. 2001. Muller glia are a potential source of neural regeneration in the postnatal chicken retina[J]. Nat Neurosci, 4: 247-252.
  • 7L awrence JM, Singhal S, Bhatia B, Keegan DJ, Reh TA, Luthert PJ, Khaw PT, Limb GA. 2007. MIOM1 cells and similar muller glial cell lines derived from adult human retina exhibit neural stem cell characteristics[J]. Stem Cells, 25: 2033-2043.
  • 8Lewis GP, Kaska DD, Vaughan DK, Fisher SK. 1988. An immunocytochemical study of cat retinal Muller cells in culture[J]. Exp Eye Res, 47: 855-868.
  • 9Limb GA, Salt TE, Munro PM, Moss SE, Khaw PT. 2002. In vitro characterization of a spontaneously immortalized human Muller cell line (MIO-M1) [J]. Invest Ophthalmol Vis Sci, 43: 864-869.
  • 10Ooto S, Akagi T, Kageyama R, Akita J, Mandai M, Honda Y, Takahashi M. 2004. Potential for neural regeneration after neurotoxic injury in the adult mammalian retina[J]. Proc Natl Acad Sci USA, 101: 13654-13659.

共引文献16

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部