伴高尿酸血症的IgA肾病临床和病理分析

Clinicopathoiogical analysis of IgA nephropathy with elevated uric acid level

目的探讨伴有高尿酸血症的IgA肾病的临床和病理特点。方法将经过肾活检明确诊断的原发性IgA肾病110例患者分为2组：尿酸正常组55例，尿酸升高组55例，比较2组临床和病理的差异。结果尿酸升高组与尿酸正常组比较，血尿素氮、血肌酐、24h尿蛋白定量、血总胆固醇、三酰甘油、低密度脂蛋白升高；肾小球损伤加重，肾小管萎缩、肾间质纤维化明显。结论伴有尿酸升高的kA肾病患者临床和病理损伤均重于尿酸正常的IgA肾病，临床上应给与重视。

Objective To study the clinicopathological features of IgA nephropathy （lgAN） with elevated uric acid level. Methods A total of 110 patients with IgAN diagnosed by biopsy were di- vided into two groups：55 patients with uric acid normal level group and 55 patients with elevated uric acid level group. Results As compared with uric acid normal level group, blood urea nitrogen, serum creatinine, 24-h urine protein, cholesterol, triglyceride, and low-density lipoprotein were increased, and the glomerular damage and tuhulointerstitial fibrosis were aggravated in elevated uric acid level group. Conclusions The clinicopathological damage in patients with IgAN and elevated uric acid level is more severe than in IgAN patients with normal level of uric acid.