1846例唇腭裂临床病例分析

Clinical Case Analysis of 1846 Cases of Cleft Lip and Palate

目的了解近年来云南省唇腭裂发病的概况,为该疾病的防治提供依据.方法对1 846名唇腭裂患者临床资料进行回顾性统计分析.结果滇东地区患者较多,其中曲靖、昭通、红河和文山地区患着占总数的55%.唇裂伴腭裂患者最多.不同类型唇腭裂患者性别构成均有统计学差异.单侧患者间左右侧发病无统计学差异(P>0.05).22例患者(22/1 846,1.14%)伴发其他畸形.193例(193/1 846,10.46%)患者亲属中有唇腭裂病史.459例(459/1 846,24.86%)唇腭裂患者母亲孕早三月有致畸危险因素暴露史.结论唇腭裂的发生可能与多基因遗传,胚胎发育早期的环境因素等有关.

Objective To acknowledge the general condition of patients of cleft lip and palate in Yunnan province for the past five years and obtain evidences for treatment and prevention of this kind of diseases.Methods Retrospective analysis of clinic material of 1 846 patients who accepted operations in our department has been performed.Results Patients from counties of Qujing,Zhaotong,Honghe and Wenshan,which located in the east part of Yunnan province,account for more than one half of total patients in this research.The number of cleft lip combined palate was more than half of total patients.The gender difference between patients of cleft lip（CL）,cleft palate（CP） and cleft lip combined palate（CLP） presented statistical value.There was no statistical difference of occurrence of cleft in left and right side in patients suffered unilateral disease.22 cases（22/1846,1.14%） accompanied other congenital deformities.193 out of 1 846（10.46%） patients revealed heredity background of similar diseases occurred in one or more family members.There were 459 cases（24.86%） pregnancy mothers exposure to risk factors in their early three months of duration of pregnancy.Conclusions It was informed that the existence of relationship between multi-genetic heredity,environmental influences during the early developing embryo and the pathogenesis of cleft lip and palate.