羟考酮缓释片治疗中重度癌痛的有效性和安全性观察

The efficacy and safety observation of oxycodone retard tablets in the treatment of moderately severe pain

目的观察羟考酮缓释片治疗中重度癌痛的有效性和安全性。方法选取本院2011年6月～2012年12月收治的癌症伴有中重度疼痛的患者78例,分为观察组40例和对照组38例,观察组给予羟考酮缓释片镇痛治疗,对照组给予吗啡缓释片治疗,观察两组治疗效果和药物不良反应。结果观察组和对照组治疗总有效率分别为82.5%、80.0%,差异无统计学意义(P>0.05),观察组和对照组药物不良反应发生率分别为50.0%、73.7%,差异具有统计学意义(P<0.05)。结论盐酸羟考酮缓释片和硫酸吗啡缓释片均可有效控制中重度癌性疼痛,但羟考酮药物安全性更高。

Objective To observe the efficacy and safety of oxycodone retard tablets in the treatment of moderately severe pain. Methods From June 2011 to December 2011, 78 patients with cancer combined with moderately severe pain, were divided into 40 cases in the observation group and 38 cases in the control group. The observation group were given oxycodone retard tablets for analgesic treatment, and the control group were given morphine retard tablets, the curative effect and adverse drug reactions of two groups were observed. Results The total effective rate of the observation group and control group were 82.5%, 80.0%, there was no statistically significant difference（P 〉 0.05）.The incidence of adverse drug reactions of the observation group and control group were 50.0%, 73.7%, the difference was statistically significant（P 〈 0.05 ）. Conclusion Oxycodone hy＇drochloride retard tablets and morphine sulfate retard tablets all can effectively control moderately severe cancer pain, but drug safety of oxycodone is higher.