新生儿高胆红素血症血清酶的改变及临床意义

Clinical significance and the changes of serum enzyme in neonatal hyperbilirubinemia

目的通过观察新生儿高胆红素血症患儿治疗前后的γ-谷氨酰转肽酶(γ-GT)、碱性磷酸酶(ALP)、谷草转氨酶(AST)、谷丙转氨酶(ALT)的变化,探讨血清酶活性检测的临床意义及高胆红素血症是否存在肝脏损伤及损伤程度。方法选择本院2010年1月～2012年12月儿科住院的新生儿高胆红素血症患儿60例,抽取患儿治疗前、后的静脉血,使用美国雅培AEROSET型全自动生化分析仪(长征牌试剂)检测肝功能及γ-GT、ALP。结果新生儿高胆红素血症治疗前γ-GT、ALP明显增高,与治疗后差异有统计学意义(P<0.01),AST亦有改变(P<0.05),而ALT治疗前后无明显变化(P>0.05)。结论新生儿高胆红素血症时患儿胆道排泄功能有问题,存在胆汁淤积。高胆红素血症有一定的肝功能损伤,但对肝细胞损害较少,需早期积极予以治疗。

Objective To observe the changes of 3＇-GT, ALP, AST, ALT in newborns with hyperbilirubinemia before and after treatment,and to study the clinical significance of seroenzyme detection and the effect of neonatal hyperhilirubinemia on the liver function. Methods The 60 cases of neonatal hyperbilirubinemia were detected from January 2010 to December 2012. The levels of serum enzyme were analyzed by AEROSET Full-Automatic biochemistry analyzer before and after treatment. Results The levels of 3＇-GT,ALP in neonatal hyperbilirubinemia patients who before treatment were much higher than that in patients with treatment.the difference were statistically significant （P 〈 0.01 ）. The difference of the level of AST was also significantly（P 〈 0.05 ）,but there was no significant difference of the level of ALT before and after treatment（P 〉 0.05 ）.Conclusion Neonatal hyperbilirubinemia patients might have some damage with the bile duct discharge function and some abnormal changes of liver function,but have a little damage with the cell of liver.The patients must be treated in time.