摘要
透明质酸是一种具有特殊生理功能的高分子多糖 ,在医药和化妆品工业中有着广泛的用途 .以兽疫链球菌 (Streptococcuszooepidemicus)为生产菌株 ,葡萄糖为碳源 ,在 2 .5L小型发酵罐上对发酵过程的动力学进行了研究 ,利用功能单元理论建立了以碳源为限制性底物的动力学模型 .采用计算机对实验数据进行的计算 ,拟合出模型参数 ;对模型的适用性进行考察 ,证明了该模型有较宽的适用范围 .
Hyaluronic acid (HA) is a kind of polysaccharide with special physical functions, and has been used widely in cosmetic and medical areas. Kinetics of HA fermentation process with glucose as carbon source by Streptococcus zooepidemicus H23 were studied in a 2.5 L fermentor. Using function unit theory, kinetic model was constructed for fermentation with carbon source as limited substrate. Parameters of model were estimated by computation of the data of experiment. Applicability was also tested.
