不同剂量阿托伐他汀对颈动脉粥样硬化的干预效果

Effect of different dose atorvastain on carotid atherosclerosis

目的探讨不同剂量阿托伐他汀对颈动脉粥样硬化干预效果。方法回顾性分析颈动脉粥样硬化患者860例,其中使用阿托伐他汀20mg治疗的420例(A组),使用10mg治疗的440例(B组),治疗6个月。在治疗前及治疗后6个月,均经颈动脉超声观察颈动脉内膜中层厚度(intima-media thickness,IMT),测高敏C-反应蛋白(high sensitivity C-reactiveprotein,hs-CRP)、血脂的变化。结果治疗6个月后,两组IMT、hs-CRP、血脂水平较治疗前明显降低(P<0.01);A组较B组IMT、hs-CRP、血脂水平降低更加显著(P<0.05)。在6个月随访期间,A组心脑血管事件发生率9.6%,B组13.6%,差异无统计学意义(P>0.05)。结论阿托伐他汀20 mg对抑制颈动脉粥样硬化的发展,减少心脑血管事件可能更具有优势。

Objective To study the effect of different dose atorvastatin on carotid atherosclerosis.Methods Eight hundred and sixty old patients with carotid atherosclerosis were randomized into atorvastatin 20 mg group （group A, n=420） and atorvastatin 10 mg group （group B, n=440） for six months. Intima-media thickness（IMT） of carotid artery, hs-CRP, serum lipids were detected before and after treatment for six months. Results IMT of carotid artery, hs-CRP, serum lipids in group A were reduced significantly after theatment compared with those before treatment, and in group A were reduced significantly compared with group B.Overall incidence of cardio-and cerebrovasular events in group A was 9.6% and in group B was 13.6%.Conclusions Atorvastain 20 mg treatment in delaying and reversing the progression of carotid atherosclerosis,and reducing cardio-and cerebrovascular events is superior to atorvastatin 10 mg treatment.