结直肠癌相关的多基因研究

A research on the genes related to colorectal cancer

序贯发生的基因突变是结直肠癌多步骤演进的重要推动力。着重介绍参与结直肠癌发生、发展的原癌基因(ras)、抑癌基因(APC、DCC、p53)、转移抑制基因(nm23)等,其中任一基因的改变都可能会引起癌症的发生或转移。研究结直肠癌发生发展的相关基因不仅可以辅助临床诊断,而且以基因及其不同产物作为靶点的生物治疗方式将成为未来有效的干预措施。

Genetic mutation is considered as the predisposition colorectal cancer. Any change of such genes as prooncogenes for the occurrence and development of （ras）, tumor suppressor genes （APC, DCC, p53）, transfer suppressor genes （nrn23, CTNNB1, MID1） and so forth may cause the occurrence or transfer of the cancer. Research on the genes related to the occurrence and development of colorectal cancer is supposed to be helpful in clinical treatment and the biotherapy targeting at such genetic mutations and their side products would be hopefully effective.