摘要
To explore the efficiency and safety of hyaluronic acid for burn victims, we searched for all the relative references, selected the references according to the inclusion criterion, assessed them critically and conducted Meta-analysis. The experimental group and the control groups have statistically significant difference in the average time for wound healing. If we make subgroup analysis according to the origin, the outcomes of both foreign study and Chinese study have statistical significance. No statistically significant difference is revealed in the incidence of adverse reaction. In terms of the healing time for diverse burn wounds, statistically significant difference exists in the superficial second-degree burn. There is no statistically significant difference in deep second-degree burn, skin-grafting sites and donor sites. It revealed that hyaluronic acid can accelerate the healing of burn on skin, especially for superficial second-degree burn. And its adverse reaction by external use is negligible.
本研究旨在对透明质酸用于烧烫伤患者的疗效及安全性进行系统评价。我们系统检索所有相关文献,根据纳入标准筛选后对纳入的研究进行严格评价和Meta分析。平均创面愈合时间结果显示,两组的差异具有统计学意义;按文献来源不同进行亚组分析:国外研究和国内研究试验组和对照组的差异均有统计学意义。不良反应方面,两组的差异没有统计学意义。不同皮损区愈合时间:浅Ⅱ度烧伤两组的差异具有统计学意义;深Ⅱ度烧伤,植皮区、供皮区差异均无统计学意义。本研究结果表明透明质酸外用能够缩短烧烫伤皮肤的愈合时间,不良反应轻微,且对浅Ⅱ度烧伤的治疗可能更有优势。
