口服避孕药预处理在体外受精-胚胎移植中的临床观察

目的为探讨促排卵周期前口服避孕药(OCP)预处理在体外受精-胚胎移植(IVF-ET)的意义。方法对2010年8月至2012年8月在本所行IVF或ICSI助孕92例患者予促性腺激素释放激动剂(GnRH-a)长方案降调节前是否使用OCP药物分为OCP治疗组50例和对照组42例进行分析,比较口服避孕药对患者促排卵的效果以及对助孕结果的影响。结果 OCP预处理明显减少卵巢功能性囊肿形成和减少周期取消率(P<0.05),而两组Gn时间、用量、获卵数、受精率、妊娠率比较无显著性。结论在IVF-ET中使用OCP预处理能减少功能性囊肿的形成,减少周期取消率,OCP联合GnRH-a能获得较好的促排卵效果。

Objective To investigate the effects of oral contraceptives pretreatment before controlled ovarian stimulation （COS） on in vitro fertilization and embryo transfer （IVF-ET）. Methods 92 patients who have received IVF-ET in our institute from August 2010 to August 2012 were selected and divided into oral contraceptives pretreatment group （n = 50） and control group （n = 42）. The outcomes of IVF-ET between these groups were studied. Results The rate of ovary functional cysts and cycle cancellations in the oral contracep- tives pretreatment group were significantly lower than that of control group （ P 〈 0.05 ）. No significant differences were found between these groups for the dose and treat time of GnRH-a, retrieved oocytes, fertilization rate, pregnant rate. Conclusion Oral contraceptives pretreatment in IVF-ET reduces the incidence of ovary functional cysts and cycle cancellations, getting a good effect on controlled ovarian stimulation.