终末期肾病微炎症状态和动脉粥样硬化的关系

Relationship between microinflammatory state with end-stage renal disease and atherosclerosis

目的探讨终末期肾病(ESRD)患者出现微炎症状态和动脉粥样硬化(AS)发生率的关系。方法随机抽选72例ESRD患者进行相关炎性因子的测定,并纳入72名健康人作为对照组进行对比研究,分析ESRD微炎症状态和AS发生率的关系。结果 ESRD患者检测血清炎症指标,显示反应蛋白(CRP)、纤维蛋白原(Fib)、白介素(IL)-6以及肿瘤坏死因子(TNF)-α等的平均水平显著高于对照组。根据有无AS病史而进行分组后发现,阳性组患者血清中CRP、IL-6、TNF-α等明显高于阴性组,差异有统计学意义(P<0.05)。结论 ESRD患者体内存在着一种微炎症的状态,与AS发生存在显著相关性,可能是ESRD引起AS心脑血管并发症的相关独立影响因素之一。

Objective To investigate the relationship between ESRD patients microinflammatory state and AS. Methods Seventy two patients with ESRD for determination of inflammatory factors were randomly selected, and 72 healthy patients were selected as the control group, the microinflammatory state in ESRD patients and the relationship between the rate of AS were analyzed. Results Serum inflammatory markers in patients with ESRD detection, display of C-reactive protein （CRP）, fibrinogen （Fib）, inter]eukin （IL）-6 and tumor necrosis factor （TNF）-the average level of ~~, were significantly higher than that of control group. While grouped according to whether have history of AS, found that the serum positive patients in CRP, IL-6, TNF- c~ were higher than that of the normal group, the difference was significant （P 〈 0.05）. Conclusion Exist microinflammatory state in ESRD patients, there is significant correlation with the occurrence of AS, may be one of the factors related to independent effects on cardiovascular and cerebrovascular complications caused by ESRD AS.