高血压脑出血后脑脊液促性腺激素释放激素(GnRH)临床分析

Clinical analysis of gonadotropin-releasing hormone in cerebrospinal fluid after hypertensive cerebral hemorrhage

目的:探讨高血压脑出血患者脑脊液中促性腺激素释放激素含量变化及临床意义。方法:临床收集106例高血压脑出血患者脑脊液标本为实验组,另外选取92例脑脊液标本为对照组。应用放射免疫技术测定患者24h、一周及二周脑脊液中促性腺激素释放激素(Gonadotropin-releasing hormone,GnRH)的含量变化。结果:测试发现高血压脑出血后促性腺激素释放激素在脑脊液中的含量有明显变化,与脑损伤程度和疾病转归有密切关系。实验组所有脑脊液标本中促性腺激素释放激素含量显著高于对照组(P<0.05)。结论:高血压脑出血患者脑脊液中促性腺激素释放激素的含量有明显改变,对疾病的临床转归有预测价值。

Objective. To study changes of gonadotropin-releasing hormone （GnRH） levels in cere- brospinal fluid after hypertensive cerebral hemorrhage and its clinical meaning. Methods： Cerebrospinal fluid of 106 cases suffered from hypertension hemorrhage was used as experimental group, cerebrospinal fluid of 92 healthy volunteers as control group. Cerebrospinal fluid gonadotropin-releasing hormone levels at time points including 24 h, 1 week and 2 weeks after onset were detected with radioimrnunoassay meth- od. Results： It shows cerebrospinal fluid gonadotropin-releasing hormone levels were correlated with the severity of cerebra damage and prognosis of the disease, Cerebrospinal fluid gonadotropin-releasing hor- mone levels of the experiment group were significant higher than that in the control group （P〈0. 05）. Conclusion. Cerebrospinal fluid gonadotropin-releasing rhage indicating it can be used for prognosis.