糖化血红蛋白筛查妊娠期糖尿病的临床意义

Glycated hemoglobin screening for gestational diabetes mellitus and its clinical significance

目的::探究妊娠期糖尿病患者中糖化血红蛋白的筛查意义。方法:选取我院产前门诊检查的孕妇220例,比较各种糖尿病筛查诊断敏感、特异性。结果:GDM组HbAlc(9.8±0.4)%;OGTT(9.2±0.3)mmol/L;FPG(9.6±0.7)mmol/L,较正常妊娠组显著增高,差异具有统计学意义(P<0.05)。在GDM筛查中HbAlc敏感性、可靠性、特异性、阳性预测为93.1%、98.0%、98.4%、81.8%,指标对比OGCT、FPG均高。结论:HbA1c在GDM患者中可实用、简单、快速、不易受干扰检测,敏感性、特异性高,在GDM筛查中具应用价值。

Objective, To explore significance of screening glycated hemoglobin in patients with gestational diabetes meliitus. Methods： A total of 220 cases of pregnant women visiting outpatient during 2012 January- March were selected. Diagnostic sensitivity and specificity of various diabetes screening were compared. Results- In the GDM group HbAlc was （9.8±0.4） , OGTT was （9.2±0.3） mmol/L, FPG was （9.6 ±0.7） mmoI/L, which were increased significantly compared with normal pregnancy group （P〈0.05）. Sensitivit3;, reliability, specificity, positive predictive rate of HbAlc in GDM screening were 93.1%, 98%, 98.4%, 81.8%, respectively, which were higher than those of OGCT, FPG. Conclusions, HbAlc is practical, simple, rapid, less susceptible to interference detection, and is of high sensitivity and specificity. It is valuanle in GDM screening.