反复自然流产患者外周血白介素水平变化检测的意义

Detection and significance of interleukins level changes in peripheral blood of recurrent spontaneous abortion

目的:探讨相关白细胞介素在反复自然流产患者体内免疫调节机制的表达及作用。方法:用酶联免疫吸附试验检测120例反复自然流产患者体内的白介素水平。结果:反复自然流产患者(研究组)外周血血清中白介素水平与正常早孕妊娠组(研究组)比较,IL-2、IL-8的含量研究组高于对照组,而IL-4、IL-6、IL-10的含量则相反,两组差异有统计学意义(P<0.05)。结论:孕妇外周血中白介素水平失衡变化可引起反复自然流产的发生。

Objective： To investigate the expression and role of interleukins in patients with recurrent spontaneous abortion （RSA） . Methods： Serum interleukins were measured by enzyme -linked immunosorbant assay （ELISA） in 120 RSA patients, which were randomly divided into early RSA and normal early pregnancy groups. Results： The serum IL -2, IL -8 in RSA group were obviously higher than those of normal control group. IL - 4, IL - 6, IL - 10 in RSA group were obviously lower than those of normal control group. Conclusion： The imbalance changes of interleukins in pregnant women would cause RSA.