D2-40在宫颈癌发展过程中表达的研究

Expression of D2-40 in the development of cervical carcinoma

目的:观察宫颈原位癌、早浸润癌和浸润癌各阶段D2-40的表达情况,研究D2-40标记的LVD数目与宫颈癌演变临床病理因素的关系。方法:采用免疫组织化学(SP法)检测30例宫颈原位癌(0期)、15例早浸润癌(IA期)、35例浸润癌(IB-IIB)D2-40,同时观察其标记的LVD在肿瘤不同阶段中的表达及与临床病理因素相关性。结果:D2-40标记的LVD在宫颈原位癌、早浸润癌和浸润癌组织中的数量分别是9.73±0.06、14.40±3.43和15.26±4.61,三组间有显著性差异(P<0.05)。淋巴结转移阳性组和阴性组LVD数量分别是18.00±5.04和14.43±3.92,有显著性差异(P<0.05)。结论:用D2-40标记LVD在宫颈原位癌和早期浸润癌、浸润癌演变过程中逐渐增加,宫颈癌的发生过程中,淋巴管数目的增多提示宫颈癌转移的风险的增加,在诊断中也有提示作用。

Objective： To detect the expression of D2 -40 in carcinoma in situ, early invasive carcinoma and invasive carcinoma of the cervix and the relationships between the LVD marked by D2 - 40 and clinical pathological factors for cervical carcinoma Methods： Cervix tissue was stained by immunohistochemistry of anti - D2 -40 in 30 cases of carcinoma in situ, 15 cases of early invasive carcinoma and 30 cases of invasive carcinoma of the cervix, and the relationships between the LVD marked by D2 - 40 and stages of the cervical carcinoma, clinical pathological factors were observed. Results： The LVD marked by D2 - 40 of carcinoma in situ, early invasive carcinoma and invasive carcinoma of the cervix was 9.73±4. 06, 14.40 ± 3.43 and 15.26 ± 4. 61 respectively, there were significant differences among three groups （P 〈 0. 05 ） . LVD in lymph node positive group was higher than that of lymph node negative group （ 18.00 ± 5.043 vs 14. 43±3. 927, P 〈0. 05） . Conclusion： LVD marked by D2 -40 is increased with the development from carcinoma in situ to early invasive carcinoma and invasive carcinoma of the cervix. Increasing number of lymphatic vessels indicates an increasing transfer risk of cervical cancer and also is helpful to diagnosis.