摘要
目的:探讨双重滤过血浆置换(DFPP)方法对高脂血症性急性胰腺炎(HLAP)的临床治疗效果。方法:5例HLAP患者采取常规胰腺炎治疗方法同时进行DFPP治疗,比较治疗前、后患者APACHEⅡ评分及血清甘油三酯(TG)浓度变化。结果:5例患者共进行7次DFPP治疗,治疗后APACHEⅡ评分均降低,平均降低(5.14±3.38)分,t=3.98,P<0.01,统计学差别明显,DFPP可以明显改善患者临床症状;治疗后血清TG浓度均降低,平均降低(18.96±13.13)mmol/L,t=3.82,P<0.01,统计学差别明显,DFPP可以迅速降低患者血清TG浓度,平均清除率为70.14%。结论:DFPP可以迅速降低患者血清TG浓度,缓解临床症状,减少异体血液制品输入,降低输血相关并发症的发生率,是一种安全有效的HLAP治疗方法。
Objective：To approach the clinical effect of double filtration plasmapheresis （DFPP） for hyperlipoidemia a cute pancreatitis by summarizing the cases and reviewing the literatures related. Methods：We compared the APACHE II and serum triglyceride between the pretherapy and posttreatment by summarizing the 5 patients suffered from hyperli poidemia acute pancreatitis who were treated with DFPP in SICU. Results： 5 patients of hyperlipoidemia acute pancreati tis were treated with DFPP seven times. There was decrease both of APACHE I1 and serum triglyceride between the pretherapy and posttreatment and the symptoms of patients were relieved. Serum triglyceride was reduced quickly by the treatment of DFPP, the average clearance was 70. 14 %. Differences between the mean APACHE IT and mean serum triglyceride were 5. 14：t：3. 38,t=3. 98,P〈0. 01 and （18. 96413. 13）mmol/L,t=3.82,P〈0. 01 respectively. There was statistics significance. Condusion：DFPP is a safety and effective treatment for hyperlipoidemia acute pancreatitis by decreasing the serum triglyeeride quickly, relieving the symptoms of patients , reducing the blood transfusion and com plications related to blood transfusion.
出处
《医学理论与实践》
2013年第10期1267-1269,1285,共4页
The Journal of Medical Theory and Practice
