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人促甲状腺激素受体及其抗体与Graves病关系研究进展 被引量：9

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摘要 Graves病（Gravesdisease，GD）是一种器官特异性自身免疫病，与桥本甲状腺炎（HT）同属自身免疫性甲状腺疾病（AITD），在西方人群的发病率为0．5％～1．0％，在中国人群中为0．25％-1．09％。患者主要临床表现为高代谢综合征，部分患者可以出现甲状腺相关眼病、黏液性水肿和／或肝脏损害。一般认为GD的易感性由遗传、环境和内在因子（免疫）共同决定，经感染、刺激等因素诱发免疫功能紊乱，
作者 王冉 张晓梅
机构地区 蚌埠医学院第一附属医院内分泌科
出处 《蚌埠医学院学报》 CAS 2013年第4期505-509,共5页 Journal of Bengbu Medical College
关键词 GRAVES病 促甲状腺素受体 促甲状腺激素受体抗体 自身免疫性甲状腺病 综述
分类号 R581.1 [医药卫生—内分泌]
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参考文献40

  • 1Chistyakov DA, Savost' anov KV, Turakulov RI, et al. Genetic determinants of Graves disease [ J ]. Mol Genet Metab, 2000, 71 (1/2) :66 -69.
  • 2张闿珍,林益川,方志平,罗长荣,刘小莺,张芳林,陈国利,吴文生,陈璇.食盐加碘10年对地方性甲状腺肿和甲状腺功能亢进症患病率的影响[J].中华内分泌代谢杂志,2002,18(5):342-344. 被引量：20
  • 3Jacobson EM, Tomer Y. The CD40, CTLA4, thyroglobulin, TSH receptor, and PTPN22 gene quintet and its contribution to thyroid autoimmunity: back to the future [ J ]. J Autoimmun, 2007, 28(2/3) :85 -98.
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二级参考文献31

  • 1张闿珍,陈美爱,林哲章,王广芬,林益川,黄国良.福州及武夷山市甲状腺疾病调查分析[J].福建医学院学报,1993,27(3):267-268. 被引量：1
  • 2Prakash A, Alison A, Christine M , et al. A systematic review of drug therapy for Graves' hyperthyroidism. Eur J Endocrinol, 2005,153:489- 498.
  • 3Allahahadia A, Daykin J, Holder RL, et al. Age and gender predict the outcome of treatment for Graves' hyperthyroidism. J Clin Endocrinol Metab, 2000, 85: 1038-1042.
  • 4Yoshimura N, Naoko M, Shuji F, et al. Ratio of serum free triiodothyronine to free thyroxine in Graves' hyperthyroidism and thyrotoxicosisi caused by painless thyroiditis. Endocrine J, 2005, 52:537-542.
  • 5David SC. Antithyroid Drugs. N Engl J Med, 2005,352: 905- 917.
  • 6Glinoer D, de Nayer P, Bex M, et al. Effects of 1-thyroxine administration, TSH-receptor antibodies and smoking on the risk of recurrence in Graves' hyperthyroidism treated with antithyroid drugs: a double-blind prospective randomized study. Eur J Endocrinol, 2001, 144:475-483.
  • 7Schott M, Morgenthaler NG, Fritzen R, et al. Levels of autoantibodies against human TSH receptor predict relapse of hyperthyroidism in Graves' disease. Horm Metab Res, 2004, 36: 92-96.
  • 8Feldt-Rasmussen U, Schleusener H, Carayon P. Meta-analysis evaluation of the impact of thyrotropin receptor antibodies on long term remission after medical therapy of Graves' disease. J Clin Endocrinol Metab, 1994,78 : 98-102.
  • 9Manji N, Carr-Smith JD, Boelaert K, et al. Influences of age, gender, smoking, and family history on autoimmune thyroid disease phenotype. J Clin Endocrinol Metab, 2006, 91: 4873- 4880.
  • 10Torring O, Tallstedt L, Wallin G, et al. Graves' hyperthyroidism: treatment with antithyroid drugs, surgery, or radioiodine-a prospective, randomized study. Thyroid Study Group. J Clin Endocrinol Metab, 1996, 81: 2986-2993.

共引文献27

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引证文献9

二级引证文献32

蚌埠医学院学报
2013年 第4期

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