醋酸钙对透析前慢性肾脏疾病患者血清磷浓度的影响

Effect of calcium acetate on serum phosphorus pre-dialysis chronic kidney disease

目的研究醋酸钙对透析前慢性肾脏疾病(CKD)患者血清磷的影响。方法 96例CKD合并高磷血症的透析前患者随机分2组:醋酸钙组(56例)与安慰剂组(40例)。根据血清磷水平,起始剂量为每次0.6 g,每2周随访1次,剂量逐步增加,每日最多9.0 g,总疗程为12周。观察2组的血清磷浓度和甲状旁腺激素浓度。结果服药后第12周,醋酸钙组血清磷浓度、甲状旁腺激素和血清碳酸氢盐均显著低于安慰剂组(P<0.05)。结论醋酸钙可明显降低透析前CKD患者的血清磷、甲状旁腺激素和血清碳酸氢盐,有效和安全。

To research the effect of calcium acetate on serum phosphorus, bicarbonate and parathyroid hormone concentrations in predialysis chronic kidney disease. Methods Nighty- six pre- dial- ysis patients with hyperphosphatemia advanced chronic kidney disease （CKD） were randomly into two groups, 56 subjects received calcium ac- etate treatment（trial group）, 40 patients in the placebo group. The ini- tial dose was 0. 6 g each time based on the serum phosphorus, followed - up once every two weeks. Then gradually increased the dose levels, up to 9.0 g daily, the total course was 12 weeks. Serum phosphorus concentra- tions and parathyroid hormone concentrations of the two groups were de- termined. Results hormone and serum after treatment were The serum phosphorus concentrations, bicarbonate in the calcium acetate group significantly lower than in the placebo 0. 05）. Conclusion Calcium acetate can effectively and serum phosphorus, bicarbonate and parathyroid hormone in CKD patients. parathyroid at 12 weeks group （ P 〈 safely on the pre - dialysis Key words： calcium acetate ; pre - dialysis ; chronic kidney disease ; ser- um phosphorus