新型醛固酮受体阻断剂——依普利酮研究进展

Progress of the novel selective mineralocorticoid receptor antagonist eplerenone

目的依普利酮是在螺内酯的基础上研发的一种新型选择性盐皮质激素受体拮抗剂。该药对心力衰竭和高血压具有良好的疗效,对肾脏具重要的保护作用,且性激素相关不良反应少。本文重点介绍依普利酮的最新临床研究进展。

Eplerenone is a novel selective mineralocorticoid receptor an- tagonist developed on the basis of spironolactone with very few sex hor- mone -related adverse reactions. The drug has a good therapeutic effect on heart failure and hypertension, and an important role in the protection of the kidney. This paper aimed to give a reivew about the latest research progress of eplerenone based on a brief introduction of the chemical structure and pharmacokinetics of this drug.