黄芪散及黄芪葛根汤调脂作用研究

Study on Lipid Regulation of Huangqi Powder and Huangqi Gegen Decoction

目的探讨黄芪散和黄芪葛根汤调节脂代谢的药理作用及作用特点。方法给予8周龄雄性SD大鼠10％果糖自由饮用5周，复制内源性高脂血症；给予8周龄SD大鼠53.3％高脂饲料13周，复制外源性高脂血症。在造模的同时灌胃给予黄芪散（HQS）、黄芪葛根汤（QG），观察血脂、血糖、胰岛素耐量、器官重量及肝脏TG等指标的变化。结果黄芪散在不影响大鼠进食进水量的情况下，显著改善饮用果糖大鼠胰岛素耐量（P〈0．05）．降低血TC、LDL—C（P〈0．05～0．001）；黄芪葛根汤仅改善胰岛素耐量（P〈0．05）。对进食高脂饲料大鼠，黄芪散显著降低血TC（P〈0．01），减轻体质量及附睾脂肪质量（P〈0．01）；而黄芪葛根汤则作用不明显（P〉0．05）。黄芪散作用优于黄芪葛根汤。结论黄芪散具有良好的调节内外源性脂代谢紊乱作用，具体机制有待进一步研究。

Objective To elucidate the pharmacological profiles of Huangqi Powder （HP） and Huangqi Gegen Decoction （QGD） for regulating lipid metabolism. Methods Endogenous hyperlipidemia model was replicated in 8-week age male rats which were administrated with 10 % fructose solution by free drinking for 5 weeks. Exogenous hyperlipidemia model was replicated in 8-week age rats which were administrated with 53.5 % high fat diet for 13 weeks. HP or QGD was simultaneously administrated by intragastric gavage during the modeling. The lipid parameters of plasma triglyceride （TG）, total cholesterol （TC）, low density lipoprotein cholesterol（LDL-C）, and serum glucose, insulin tolerance, organ weight and hepatic TG were investigated. Results HP improved insulin tolerance （P 〈 0.05） and reduced plasma TC, LDL-C （P 〈 0.05-0.001 ）, on the basis of having no impact on food intake and water intake in fructose-drinking rats. QGD only improved insulin tolerance（P 〈 0.05 ）. In high-fat-feeding rats, HP decreased plasma TC, body weight and epididymal fat weight （P 〈 0.01 ）. However, QGD had no obvious effect. HP had better pharmacological effects than QGD. Conclusion HP has better regulation effect on endogenous and exogenous hyperlipidemian, and the mechanism needs to be further studied.