替吉奥联合多西他赛与FOLFOX4治疗晚期胃癌的比较

Comparison of S-1 combined with docetaxel and FOLFOX4 in the treatment of advanced gastic carcinoma

目的比较替吉奥胶囊（S-1）联合多西他赛与~FQLFOX4方案治疗晚期胃癌的临床疗效及安全性。方法将75例初治和复治的晚期胃癌患者随机分为实验组和时照组。窦验鲤37倒，应用替吉奥胶囊80mg／m2，口服，早晚餐后各1次，第1-14天；多西他赛38mg／m2，第1、8天，静脉滴注lh。21d为l今化疗周期，至少完成2个周期。对照组38例应用FOLFOX4方案，即；奥沙利铂85mg／m。静脉注射2h，第1天；亚叶酸钙200mg/m2静脉滴注，第1、2天；5一氟脲嘧啶（5．Fu）400mg／m2，静脉推注，第l奏；5-Fu600mg／m2，持续静脉滴注22h，第1、2天。14d为1个周期，至少完成2个周期。评价两组的客观疗效及不良反应。结果实验纽和对照组的有效率分别为56．76％、47．37％，两组比较差异无统计学意篡（P〉0．05）。实验组和对照组的腹泻及恶心、呕吐的发生率均较对照组低，差异有统计学意义（P均〈0.05）。其他毒副作用比较差异无统计学意义（P均〉0．05）。结论替吉奥联合多西他赛与FOLFOX方案近期疗效秃明显差异，但替吉奥联合多西他赛毒副作用较轻，对年劳体弱者可能重逢合．

Objective To compare the curative efficacy and safety of the combination of S-1 and docetaxel and FOLFOX4 in the treatment of pgtients with advanced gastic carcinoma. Methods Seven- ty-five patients with advanced gastric carcinoma ware group（37 cases） were treated with the combination of S-1 c covered 3 weeks. Control group were treated with FOLFOX4 divided into two groups. Experimental and docetaxel, one treatment cycle therapy, 14 days as a cycle. The efficacy and toxicity were evaluated after 2 cyeles. Results The overall effective rate control group was 56. 76% and 47.37% respectively, There was no significant of experimental group and difference between the two groups （P〉0.05 ）： The main adverse reactions included myelo-depression, nausea, vomiting and diarrhea. Conclusions Two groups have similar effects in the treatment of advanced gastric carcinoma, and the toxicity of the regi- ment of S-1 combined with docetaxel is mild and tolerable.