雌激素及胆红素与绝经后女性冠心病相关性分析

Correlation of estrogen and serum bilirubin on postmenopausal women with coronary heart disease

目的研究雌激素及胆红素与绝经后女性冠心病发生的相关性。方法选取绝经后可疑女性冠心病患者106例，根据冠状动脉造影结果分为非冠心痛组（55例）和冠心病组（51例），比较两组患者血雌二醇、总胆红素、直接胆红素、间接胆红素水平。结果冠心病组患者血雌二醇、总胆红素明显低于非冠心病组（P〈0．05），直接胆红素、间接胆红素水平两组比较差异无统计学意义（P〉0．05）；雌激素与总胆红素水平呈正相关（P〈0．05）。结论绝经后女性冠心病的发生可能与低水平的雌激素及胆红素有关，雌激素对女性体内胆红素的代谢有重要作用。

Objective To study the correlation of estrogen and serum bilirubin with occurrence of coronary heart disease among the postmenopausal women. Methods One hundred and six suspicious postmenopausal female patients with coronary heart disease were selected. They were divided into CHD group （51 cases） and non-CHD group （55 cases）according to the result of coronary angiography. Com- pare the levels of Estradiol （ E2 ） , total bilirubin （ TBIL）, direct bilirubin （ DBIL）, indirect bilirubin （IBIL） in the two groups. Results The levels of E2, TBIL were lower in CHD group than those of non- CHD group （ P 〈 0. 05 ）. The difference of DBIL and TBIL had no statistically significant difference be- tween the two groups （P 〉 0. 05 ）. Conclusions The low level of estrogen and bilirubin may involve in the occurrence of coronary heart disease among postmenopausal women. Estrogen plays an important role in the bilirubin metabolism of women.