中国2010年<15岁儿童吉兰-巴雷综合征流行病学分析

Epidemiological Analysis of Guillian-Barr é Syndrome among Children Less than 15 Years Old in China, 2010

目的了解中国(未包括香港、澳门特别行政区和台湾地区,下同)2010年<15岁儿童吉兰-巴雷综合征(Guillian-Barré Syndrome,GBS)的流行病学特征、临床表现、实验室检测结果和麻痹残留情况,并探索影响GBS预后的因素。方法对中国2010年免疫规划监测信息管理系统中,<15岁儿童急性弛缓性麻痹(Acute Flaccid Paralysis,AFP)病例个案数据进行分析。结果中国2010年AFP病例监测系统共报告<15岁儿童GBS1033例,报告发病率为0.42/10万。上、下肢均发生麻痹、严重麻痹和粪便标本中分离出非脊髓灰质炎肠道病毒(Non-polio Enterovirus,NPEV)的GBS预后较差。结论 GBS在中国2010年<15岁儿童AFP病例中占居首位,有必要加强对GBS的管理,尤其是上、下肢均发生麻痹、严重麻痹和NPEV阳性的病例。

Objective To learn epidemiological characteristics, clinical manifest, laboratory results and residual paralysis of Guillian-Barr6 syndrome （GBS） among children who were 〈 15 years old in 2010, and to explore the factors associated with GBS prognosis in China （excluding Hong Kong Special Administrative Region, Macao Special Administrative Region, Taiwan Sheng; similarly hereinafter）. Methods The individual data of acute flaccid paralysis （AFP） cases 〈15 years old from surveillance system of information on national immunization program in China in 2010 was analyzed. Results 1033 GBS〈 15 years old were reported in AFP cases surveillance system in China in 2010, and the reported incidence of GBS is 0.42/100,000. GBS with paralysis of upper and lower limb, severe paralysis or non-polio enterovirus （NPEV） positive in stool specimens had worse prognosis. Conclusion GBS is the leading cause of AFP cases among the children〈 15 years old in China in 2010. It is necessary to strengthen GBS management, especially for GBS with paralysis of upper and lower limb, severe paralysis or NPEV positive.