摘要
目的分析宫颈癌患者的预后影响因素。方法选择2004年3月～2009年12月在邯郸市中心医院妇科治疗的宫颈癌患者92例,组间生存率的比较采用Log-rank检验,采用Cox比例风险模型进行多因素分析,探讨宫颈癌的预后影响因素。结果 Log-rank检验显示,临床分期、淋巴结转移、宫旁浸润或脉管瘤栓、环氧合酶-2(COX-2)阳性、人乳头瘤病毒16-E6蛋白(HPV16-E6)阳性与预后有关(P<0.05),而年龄、病理类型、宫颈肌层浸润深度与预后无关(P>0.05)。Cox比例风险模型结果显示,临床分期、淋巴结转移、宫旁浸润或脉管瘤栓、COX-2阳性、HPV16-E6阳性与宫颈癌预后显著相关(P<0.05);而肿瘤分化程度、病灶直径与宫颈癌预后无关(P>0.05)。结论淋巴结转移、宫旁浸润或脉管瘤栓、COX-2、HPV16-E6为宫颈癌的独立预后因素。
Objective To investigate the prognostic significance in 92 patients with cervical cancer.Methods 92 patients with cervical cancer in Central Hospital of Handan City from March 2004 to December 2009 were selected,Log-rank examination was used to compare the survival rate,Cox proportional hazard model was used to take the mul tiple-factor analysis in prognosis of cervical cancer.Results Significant correlation were found between the clinical stages,lymphatic metastasis,parametrial infiltration or vascular tumors bolt,positive of Cox-2,positive of HPV16-E6 and prognosis according to the Log-rank examination（P 0.05）;significant correlation was not found between age,pathological pattern,cervical muscle layer infiltration depth with prognosis（P 0.05）.Significant correlation were found between the clinical stages,lymphatic metastasis,parametrial infiltration or vascular tumors bolt,positive of Cox-2,positive of HPV16-E6 and prognosis according to the Cox proportional hazard model（P 0.05）;significant correlation was not found between tumor differentiation degree,diameter of lesions and prognosis（P 0.05）.Conclusion Lymphatic metastasis,parametrial infiltration or vascular tumors bolt,COX-2 and HPV 16-E6 are independent prognostic factors with cervical cancer prognosis.
出处
《中国医药导报》
CAS
2013年第15期63-65,68,共4页
China Medical Herald
