经内镜微波凝固联合雷贝拉唑治疗Barrett食管疗效观察

CURATIVE EFFECT OF ENDOSCOPIC MICROWAVE COAGULATION COMBINED WITH RABEPRAZOLE FOR TREATMENT OF BARRETT'S ESOPHAGUS

目的观察内镜下微波凝固联合雷贝拉唑治疗Barrett食管的临床疗效。方法选择经胃镜及病理检查确诊的Barrett食管患者55例,随机分为治疗组(28例)和对照组(27例)。治疗组以内镜下微波凝固后,给予口服雷贝拉唑20mg/d,抑酸治疗,对照组仅口服雷贝拉唑20mg/d,二组均治疗12个月。观察治疗后症状的改善及3,6,12个月内镜和病理复查情况。结果二组的临床症状均较治疗前明显改善,症状缓解率差异无统计学意义(P>0.05),治疗组Barrett食管上皮逆转总有效率3,6,12个月时分别为64.29%、67.86%和78.57%,而对照组则分别为0,0,14.81%,差异有统计学意义(P<0.05)。结论内镜下微波凝固联合雷贝拉唑治疗Barrett食管,效果优于单用抑酸剂。

Objective To explore the clinical effect of endoscopic microwave coagulation combined with Rabeprazole for treatment of Barrett＇s esophagus. Methods Fifty - five patients who were diagnosed as Barrett% esophagus by gastroscopy and pathology were randomly divided into treatment group （n= 28） and control group （n = 27）. The treatment group were treated with microwave coagulation under endoscope, Rabeprazole（20mg/day） was given oral to suppress acid, the control group only oral Rabeprazole（20mg/ day）, all patients were followed- up for 12 months. Improvement of symptoms were observed after treatment and endoscope and pathology checked methods were performed after 3, 6, 12 months for all cases. Results The clinical symptoms of patients were significantly improved after treatment in two groups, but their symptom relief rate was no significant difference （P〈0. 05）. Barrett＇s esophageal epithelium reverse the total effective rate of 3, 6 and 12 months were 64.290%, 67.86% ,78. 57% respectively for treatment group, and 0, 0, 14.81% for control group, there was a significant difference between two groups（P〈 0.05）. Conclusion Endoscopic microwave coagulation combined with Rabeprazole for the treatment of Barrett＇s esophagus is a more effective means than acid inhibitor only.