肺结核患者维生素A、维生素E和β-胡萝卜素营养状况及机体抗氧化酶水平分析

Vitamin A,vitamin E and β-carotene nutritional status and antioxidase level analysis among tuberculosis patients

目的了解肺结核患者维生素A(VA)、维生素E(VE)和β-胡萝卜素(β-C)营养状况及机体抗氧化酶水平。方法随机抽取临沂市郯城县结核病防治所2010年就诊的70例肺结核患者作为病例组,匹配选取该地同期正常健康人群70例作为对照组。两组人群均进行相关营养指标检测,包括基本营养状况,如体质指数(BMI)、血红蛋白(Hb);血脂水平分析,如甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL);抗氧化酶水平分析,包括超氧化物歧化酶(SOD)和过氧化氢酶(CAT);机体VA、VE和β-C水平。结果病例组的BMI为19.13,明显低于对照组21.95(P<0.05),而病例组Hb为128.36g/L,低于对照组的131.30g/L,但差异无显著性。血脂水平分析显示病例组TG、TC和HDL含量分别为1.54、4.47和1.21mmol/L,均低于对照组相应的含量(1.63、5.20和1.30mmol/L)(P<0.05)。抗氧化酶水平比较显示病例组的SOD和CAT水平分别为78.20和5.24U/ml,对照组两者的水平分别为83.27和9.99U/ml,病例组明显低于对照组(P<0.05);维生素水平分析显示病例组的VA和VE含量0.256和1.148μg/ml,均显著低于对照组的0.385和1.182μg/ml(P<0.05),但病例组的β-C含量为0.048μg/ml,略低于对照组的0.051μg/ml,差异无显著性。结论肺结核患者的自身营养状况较差,体内抗氧化酶和VA、VE、β-C水平均显著低于正常人群。

Objective To investigate vitamin A（VA）,vitamin E（VE） and β-carotene nutritional status and antioxidase level among tuberculosis patients.Methods Totally 70 tuberculosis patients were randomly selected as the experiment group from Tancheng Tuberculosis Control in 2010.And 70 matched normal persons were selected as the control group.Two groups of people were relative nutrition index test which include body mass index（BMI）,hemoglobin（Hb）,triglyceride（TG）,total cholesterol（TC）,high-density lipoprotein（HDL）,superoxide dismutase（SOD）,catalase（CAT）,VA,VE and β-carotene.Results BMI of the experiment group was 19.13,which was obviously lower than those of the control group which was 21.95（P0.05）,but Hb of the experiment group was 128.36g/L which was lower than those of the control group,not with significant statistic differences.For blood lipid level,TG,TC,HDL of the experiment group were 1.54,4.47 and 1.21mmol/L respectively,compared with corresponding indexes of the control group which were 1.63,5.20,1.30mmol/L respectively,were all dramatic decline（P0.05）.Antioxidase level contrast between two groups showed that SOD and CAT of the experiment group were 78.20 and 5.24U/ml respectively,and corresponding indexes of the control group were 83.27 and 9.99 U/ml respectively,so the former was significantly lower than the later（P0.05）;compared with the control group on vitamin level,VA,VE of the experiment group were 0.256 and 1.148μg/ml respectively which were all lower than the control group which were 0.385 and 1.182μg/ml（P0.05）,but β-carotene of the experiment group was 0.048μg/ml which was slightly lower than 0.051μg/ml of the control group,not with significant statistic differences.Conclusion Nutritional status among the tuberculosis patients is quite poor,especially antioxidase and VA,VE and β-carotene level are significantly lower than normal people.