响应面法优化超临界CO_2萃取亚麻籽木脂素

Optimization of Supercritical CO_2 Extraction of Lignans from Flax Seed Using Response Surface Methodology

以亚麻籽为原材料,利用响应面法优化超临界CO2萃取亚麻木脂素的工艺。在单因素试验基础上,以萃取压力、萃取温度和萃取时间为影响因素,应用Box-Behnken方法进行三因素三水平试验,以木脂素得率为响应值,进行响应面分析。确定萃取的最佳工艺条件是萃取压力25.69MPa、萃取温度41.54℃、萃取时间182.80min,亚麻籽木脂素得率的预测值为2.401%,验证值为2.398%。结果表明利用响应面分析方法对超临界CO2萃取亚麻木脂素的工艺条件进行优化,可获得最优的工艺参数,从而为进一步的研究提供依据。

The present study aimed to optimize supercritical carbon dioxide extraction of lignans from flaxseed using response surface methodology based on a 3-variable,3-level Box-Benhnken design.The results showed that the optimum conditions were extraction pressure of 25.69 MPa,extraction temperature of 41.54 ℃,extraction time of 182.80 min.Under these conditions,the model predicted and experimental values of lignans yield were 2.401% and 2.398%,respectively.